PK simulator

About

This Shiny App was developed to be used as an educational tool to understand common PK concepts. Adapted from PMX solutions.

Basic simulation information

Route of administration

I.V. bolus

Depot

Dose (mg)

Dosing frequency

Simulation time

PK Parameters

Clearance - CL (L/h)

Volume - Vc (L)

Ka (1/h)

Bioavailability (F)

Peripheral volume

Inter-compartmental clearance

Variability

Number of virtual patients

Inter-individual variability (IIV)

ETA CL

ETA Vc

ETA F

Residual Error

Proportional error

Additive error (mg/L)

Plot specifications

Predictive Interval

Minimal probability

Maximal probability

Units

Drug MW (g/mol) (optional)

convert to uM

yes

Aesthetics

Linetype

line

point

Add cutoffs: y = ?

Simulated PK Profile

Download simulated data .csv

Download .csv